Session: Innovative Approaches
Session Chair: Chara Litou & Bhagwat Prasad
New Approach Methodologies and PBPK integration
Bhagwat Prasad, Cincinnati Children’s Hospital
A review of virtual twins in PBPK
Emily Mannix, Monash University
State-of-the-Art Cluster Gauss-Newton method redefines what PBPK models can address in early clinical development
Toshiaki Tsuchitani, Keio University
Comparative Evaluation of Standard PBPK, High-Throughput PBPK and Structure-Based Machine Learning for FIH predictions
Silvan Kaeser, Roche
Liquid Biopsy–Informed Physiologically Based Pharmacokinetic Modeling of Systemic Exposure to Tyrosine Kinase Inhibitors in Leukemia
Amit Dahal, Rhode Island
Session: Oral Absorption
Session Chair: André Dallmann & Nikoletta Fotaki
Food effect prediction of a BCS class II drug formulated as an ASD
Paul Vrenken, Pharmetheus
PBBM of Regional and Colon Absorption in Humans
Harshad Jadhav, AZ
Establishing a PBBM framework to investigate the absorption process of poorly soluble drugs administered as ASDs
Julia Macente, J&J
From Dissolution to PBPK: A Probabilistic, Literature-Driven Framework for Risk-Informed Bioequivalence Evaluation
Jhennifer Rabelo, Universidade de São Paulo
Download the full program
PBPK Conference 2026 